Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 5/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568861 | 0.76 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL8522671 | 0.76 | ITGB1 (0.35) | EDNRAEDNRBKDM4CNPC1RAB9A | |
| SCHEMBL7568989 | 0.69 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL7567982 | 0.68 | NPC1 (0.44) | ALDH1A1MEN1KMT2AMAPTHTR1A | |
| SCHEMBL7814508 | 0.67 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL7566546 | 0.67 | KDM4C (0.40) | ALDH1A1MEN1KMT2AHTR1AKDM4C | |
| SCHEMBL11168223 | 0.66 | MEN1 (0.44) | ALDH1A1MEN1KMT2AMAPTKDM4C | |
| SCHEMBL12510434 | 0.65 | MEN1 (0.49) | ALDH1A1MEN1KMT2AMAPTKDM4C | |
| SCHEMBL871773 | 0.65 | KMT2A (0.55) | ALDH1A1MEN1KMT2AKDM4C | |
| SCHEMBL8354599 | 0.65 | KDM4C (0.38) | MEN1KMT2AKDM4CNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962682-A | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |