Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.80 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.80 |
| ▸ | HPGD | P15428 | 1/20 | 0.80 |
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | BCL6 | P41182 | 1/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995583 | 0.93 | EGFR (0.73) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8317916 | 0.92 | EGFR (0.72) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6995293 | 0.91 | EGFR (0.70) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8486069 | 0.91 | EGFR (0.70) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6993837 | 0.91 | EGFR (0.70) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8486251 | 0.90 | EGFR (0.69) | EGFRERBB2HPGDHTTMAPT | |
| Falnidamol SCHEMBL158563 | 0.89 | EGFR (1.00) | EGFRERBB2HPGDHTTMAPT | |
| Falnidamol SCHEMBL29387986 | 0.89 | EGFR (1.00) | EGFRERBB2HPGDHTTMAPT | |
| Falnidamol SCHEMBL29409569 | 0.88 | EGFR (0.98) | EGFRERBB2HPGDHTTMAPT | |
| Falnidamol SCHEMBL29403789 | 0.88 | EGFR (0.98) | EGFRERBB2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |