Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401614 | 0.83 | KDM4E (0.42) | KDM4ECYP2C19ALDH1A1MAPTPOLB | |
| SCHEMBL7452148 | 0.81 | KDM4E (0.41) | KDM4ECYP2C19ALDH1A1MAPTPOLB | |
| SCHEMBL6275446 | 0.81 | KDM4E (0.41) | KDM4ECYP2C19ALDH1A1MAPTPOLB | |
| SCHEMBL197940 | 0.80 | KDM4E (0.61) | KDM4ECYP2C19ALDH1A1MAPTPOLB | |
| SCHEMBL197942 | 0.80 | KDM4E (0.61) | KDM4ECYP2C19ALDH1A1MAPTPOLB | |
| SCHEMBL29380732 | 0.80 | KDM4E (0.61) | KDM4ECYP2C19ALDH1A1MAPTPOLB | |
| SCHEMBL197941 | 0.80 | KDM4E (0.61) | KDM4ECYP2C19ALDH1A1MAPTPOLB | |
| Hydrochloric Acid SCHEMBL4835592 | 0.79 | KDM4E (0.59) | KDM4ECYP2C19ALDH1A1MAPTPOLB | |
| Hydrochloric Acid SCHEMBL17604963 | 0.79 | KDM4E (0.59) | KDM4ECYP2C19ALDH1A1MAPTPOLB | |
| Hydrochloric Acid SCHEMBL4835584 | 0.79 | KDM4E (0.59) | KDM4ECYP2C19ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880159-A | TREATING ACUTE NEUROLOGICAL TRAUMATIC DISORDER OR NEUROTRAUMA | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1999-03-09 | — | — | US | disclosed |
| US-5639913-A | TREATMENT OF PARKINSON'S DISEASE, DEMENTIA, EPILEPSY | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1997-06-17 | — | — | US | disclosed |