Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.54 |
| ▸ | PPARG | P37231 | 7/20 | 0.54 |
| ▸ | PPARD | Q03181 | 7/20 | 0.54 |
| ▸ | PPARA | Q07869 | 7/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.54 |
| ▸ | TLR2 | O60603 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | FABP4 | P15090 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.54 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL114261 | 0.96 | AKR1B1 (0.61) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 | |
| Adipic Acid SCHEMBL28211417 | 0.96 | AKR1B1 (0.61) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 | |
| Octanedioate SCHEMBL28664971 | 0.93 | FFAR4 (0.64) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 | |
| Adipic Acid SCHEMBL27696357 | 0.93 | FFAR4 (0.59) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 | |
| Azelaic Acid SCHEMBL28280754 | 0.93 | FFAR4 (0.64) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 | |
| SCHEMBL28879567 | 0.93 | FFAR4 (0.64) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 | |
| Sebacic Acid SCHEMBL5475795 | 0.93 | FFAR4 (0.64) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 | |
| SCHEMBL28849696 | 0.93 | FFAR4 (0.64) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 | |
| Adipic Acid SCHEMBL31152667 | 0.92 | FFAR4 (0.53) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 | |
| Adipic Acid SCHEMBL437561 | 0.91 | FFAR4 (0.57) | FFAR4FFAR1AKR1B1ALDH1A1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908894-A | CROSSLINKING; BLEND CONTAINING CHAIN EXTENDERS, CATALYST; COMMINUTED FORM | BASF AKTIENGESELLSCHAFT (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0051211-A1 | Use of carbonic-acid/carbamic-acid anhydrides as CO2-cleaving blowing agents in the production of cellular or foam-like plastics | BAYER AG (DE) | 1982-05-12 | — | — | EP | disclosed |
| US-4132840-A | Process for coloring polyurethane foams | BAYER AKTIENGESELLSCHAFT (DE) | 1979-01-02 | — | — | US | disclosed |
| US-4026931-A | AZO DYES, FIBER-REACTIVE; INDOLE OR 5-AMINO-PYRAZOLE COUPLING COMPONENT | BAYER AKTIENGESELLSCHAFT (DT) | 1977-05-31 | — | — | US | disclosed |