SCHEMBL8523674

SCHEMBL8523674

CN(C)S(=O)(=O)n1cnc(S(=O)(=O)n2cnc(-c3ccccc3)c2)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.43
FAAH O00519 1/20 0.36
MAPT P10636 5/20 0.33
SMN1; SMN2 Q16637 4/20 0.33
ALDH1A1 P00352 4/20 0.33
LMNA P02545 2/20 0.33
RAB9A P51151 4/20 0.32
NPC1 O15118 3/20 0.32
NLRP3 Q96P20 1/20 0.32
KDM4E B2RXH2 3/20 0.32
GAA P10253 1/20 0.32
PIK3CD O00329 1/20 0.31
PIK3R1 P27986 1/20 0.31
PIK3CA P42336 1/20 0.31
PIK3CB P42338 1/20 0.31
PIK3CG P48736 1/20 0.31
NPSR1 Q6W5P4 3/20 0.31
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
TP53 P04637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2184244 0.81 TSHR (0.54) TSHRFAAHMAPTSMN1; SMN2ALDH1A1
SCHEMBL23380671 0.73 TSHR (0.38) TSHRMAPTSMN1; SMN2ALDH1A1LMNA
SCHEMBL5888283 0.72 TSHR (0.43) TSHRMAPTSMN1; SMN2ALDH1A1LMNA
SCHEMBL24776605 0.69 KDM4E (0.36) TSHRSMN1; SMN2KDM4EGAANPSR1
SCHEMBL28894119 0.68 KMT2A (0.50) TSHRMAPTSMN1; SMN2ALDH1A1LMNA
SCHEMBL7688500 0.68 TSHR (0.38) TSHRMAPTSMN1; SMN2ALDH1A1LMNA
SCHEMBL4046417 0.68 MEN1 (0.40) TSHRMAPTSMN1; SMN2ALDH1A1LMNA
SCHEMBL3821407 0.68 KDM4E (0.35) TSHRSMN1; SMN2KDM4EGAANPSR1
SCHEMBL10715481 0.68 NPC1 (0.42) TSHRFAAHMAPTALDH1A1RAB9A
SCHEMBL31354831 0.68 SMN1; SMN2 (0.47) TSHRMAPTSMN1; SMN2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11302276-A None JP disclosed
JP-H11302276-A SULFAMOYL TRIAZOL DERIVATIVE AND FUNGICIDE COMPOSITION FOR AGRICULTURAL AND HORTICULTURAL USE NISSAN CHEM IND LTD 1999-11-02 JP disclosed