Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 12/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | NMBR | P28336 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1414845 | 0.84 | SIRT2 (0.41) | SIRT2ENPP2CYP11B1CYP11B2NMBR | |
| SCHEMBL17275465 | 0.82 | SIRT2 (0.39) | SIRT2ENPP2CYP11B1CYP11B2NMBR | |
| SCHEMBL17275466 | 0.82 | SIRT2 (0.39) | SIRT2ENPP2CYP11B1CYP11B2NMBR | |
| SCHEMBL17275443 | 0.79 | SIRT2 (0.40) | SIRT2ENPP2CYP11B1CYP11B2NMBR | |
| SCHEMBL1040045 | 0.77 | CYP11B1 (0.41) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL28616157 | 0.77 | SIRT2 (0.38) | SIRT2CYP11B1CYP11B2NMBR | |
| SCHEMBL28616160 | 0.77 | SIRT2 (0.38) | SIRT2CYP11B1CYP11B2NMBR | |
| SCHEMBL5682164 | 0.76 | CYP11B1 (0.43) | SIRT2ENPP2CYP11B1CYP11B2FLT3 | |
| SCHEMBL670904 | 0.76 | CYP11B1 (0.43) | SIRT2ENPP2CYP11B1CYP11B2 | |
| SCHEMBL4030251 | 0.75 | SIRT2 (0.40) | SIRT2CYP11B1CYP11B2NMBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990317-A | HISTAMINE H3 RECEPTOR ANTAGONIST FOR TREATING CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-11-23 | — | — | US | disclosed |