Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 8/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524564 | 1.00 | AR (0.60) | ARKCNH2SRD5A2 | |
| SCHEMBL8924172 | 0.94 | AR (0.54) | ARKCNH2 | |
| SCHEMBL8525401 | 0.93 | AR (0.60) | ARKCNH2SRD5A2 | |
| SCHEMBL8525403 | 0.93 | AR (0.60) | ARKCNH2SRD5A2 | |
| SCHEMBL8525501 | 0.92 | AR (0.62) | ARKCNH2SRD5A2 | |
| SCHEMBL8525503 | 0.92 | AR (0.62) | ARKCNH2SRD5A2 | |
| SCHEMBL8525164 | 0.92 | AR (0.58) | ARKCNH2SRD5A2 | |
| SCHEMBL8525163 | 0.92 | AR (0.58) | ARKCNH2SRD5A2 | |
| SCHEMBL8496657 | 0.87 | AR (0.63) | ARKCNH2SRD5A2 | |
| SCHEMBL8496662 | 0.87 | AR (0.63) | ARKCNH2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649431-B1 | 17-AMINO SUBSTITUTED 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS | MERCK & CO INC (US) | 1999-08-11 | — | — | EP | claimed |
| EP-0649431-A4 | 17-AMINO SUBSTITUTED 4-AZASTEROID 5-G(A)-REDUCTASE INHIBITORS. | — | 1995-05-03 | — | — | EP | claimed |
| EP-0649431-A1 | 17-AMINO SUBSTITUTED 4-AZASTEROID 5$g(a)-REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1995-04-26 | — | — | EP | claimed |