Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7117641 | 0.85 | EGFR (0.44) | EGFRPDGFRBERBB2 | |
| SCHEMBL7117634 | 0.84 | EGFR (0.43) | EGFRPDGFRBERBB2 | |
| SCHEMBL7117699 | 0.78 | EGFR (0.45) | EGFRPDGFRBERBB2 | |
| SCHEMBL7123160 | 0.77 | EGFR (0.63) | EGFRPDGFRBERBB2 | |
| SCHEMBL7120334 | 0.74 | EGFR (0.57) | EGFRERBB2 | |
| SCHEMBL7128565 | 0.74 | EGFR (0.45) | EGFRPDGFRBERBB2 | |
| SCHEMBL7120649 | 0.73 | EGFR (0.44) | EGFRERBB2 | |
| SCHEMBL7128562 | 0.73 | EGFR (0.44) | EGFRPDGFRBERBB2 | |
| SCHEMBL7126747 | 0.73 | EGFR (0.39) | EGFRERBB2 | |
| SCHEMBL8644693 | 0.73 | EGFR (0.69) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006396-A1 | IRREVERSIBLE BICYCLIC INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |