⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8775250 | 0.79 | — | — | |
| SCHEMBL238623 | 0.77 | — | — | |
| SCHEMBL18227180 | 0.76 | — | — | |
| SCHEMBL2744397 | 0.76 | — | — | |
| SCHEMBL29207746 | 0.76 | — | — | |
| SCHEMBL7049695 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL11313915 | 0.75 | — | — | |
| SCHEMBL12723411 | 0.75 | — | — | |
| SCHEMBL4279740 | 0.75 | CYP3A4 (0.38) | — | |
| SCHEMBL26382870 | 0.75 | TDP1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4559915-A1 | PIPERIDINYL-METHYL-PURINEAMINES AS NSD2 INHIBITORS AND ANTI-CANCER AGENTS | Novartis AG (CH) | 2025-05-28 | — | — | EP | disclosed |
| US-12312353-B2 | Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents | NOVARTIS AG (CH) | 2025-05-27 | — | — | US | disclosed |
| EP-4013755-B1 | PIPERIDINYL-METHYL-PURINEAMINES AS NSD2 INHIBITORS AND ANTI-CANCER AGENTS | NOVARTIS AG (CH) | 2025-01-08 | — | — | EP | disclosed |
| CN-114585622-B | Piperidinyl-methyl-purinamines as NSD2 inhibitors and anticancer agents | 诺华股份有限公司 | 2024-08-09 | — | — | CN | disclosed |
| US-20230002388-A1 | PIPERIDINYL-METHYL-PURINEAMINES AS NSD2 INHIBITORS AND ANTI-CANCER AGENTS | CHINA NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH CO., LTD. (CN) | 2023-01-05 | — | — | US | disclosed |
| US-11420970-B1 | Piperidinyl-methyl-purineamines as NSD2 inhibitors and anti-cancer agents | NOVARTIS AG (CH) | 2022-08-23 | — | — | US | disclosed |
| EP-4013755-A1 | PIPERIDINYL-METHYL-PURINEAMINES AS NSD2 INHIBITORS AND ANTI-CANCER AGENTS | Novartis AG (CH) | 2022-06-22 | — | — | EP | disclosed |
| CN-114585622-A | Piperidinyl-methyl-purinamines as NSD2 inhibitors and anticancer agents | 诺华股份有限公司 | 2022-06-03 | — | — | CN | disclosed |
| WO-2021028854-A1 | PIPERIDINYL-METHYL-PURINEAMINES AS NSD2 INHIBITORS AND ANTI-CANCER AGENTS | NOVARTIS AG (CH) | 2021-02-18 | — | — | WO | disclosed |
| US-6008347-A | N-substituted 2-azetidinones | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| US-5466442-A | Cholesteryl silicone derivative and cosmetic composition comprising the same | KAO CORPORATION (JP) | 1995-11-14 | — | — | US | disclosed |
| EP-0431838-B1 | Nonionic radiographic contrast agents | BRACCO INT BV (NL) | 1995-10-25 | — | — | EP | disclosed |
| US-5412092-A | N-substituted 2-azetidinones | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0627418-A1 | N-subtituted 2-azetidinones and processes for the production of N-unsubstituted 2-azetidinones therefrom | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-07 | — | — | EP | disclosed |
| EP-0523738-A1 | Silicone derivative and cosmetic composition comprising the same | KAO CORPORATION (JP) | 1993-01-20 | — | — | EP | disclosed |
| US-5128371-A | Acylated naphthlamines as plant fungicides | CIBA-GEIGY CORPORATION (US) | 1992-07-07 | — | — | US | disclosed |
| EP-0431838-A1 | Nonionic radiographic contrast agents | BRACCO INTERNATIONAL B.V. (NL) | 1991-06-12 | — | — | EP | disclosed |
| EP-0018510-B1 | N-ACYLATED ALPHA-NAPHTHYL AMINES, THEIR PREPARATION AND THEIR USE AS PLANT FUNGICIDES, AND PLANT-FUNGICIDAL AGENTS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1983-12-21 | — | — | EP | disclosed |
| US-4275079-A | Fungicidal N-alkynylanilides | HOFFMANN-LA ROCHE INC. (US) | 1981-06-23 | — | — | US | disclosed |
| EP-0018510-A1 | N-acylated alpha-naphthyl amines, their preparation and their use as plant fungicides, and plant-fungicidal agents containing them | CIBA-GEIGY AG (CH) | 1980-11-12 | — | — | EP | disclosed |