Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 5/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8265513 | 0.81 | HTT (0.47) | HTTDHODHFGFR1FGFR2FGFR3 | |
| SCHEMBL5994439 | 0.81 | HTT (0.47) | HTTDHODHFGFR1FGFR2FGFR3 | |
| SCHEMBL1759078 | 0.78 | SMN1; SMN2 (0.47) | HTTDHODHFGFR1FGFR2FGFR3 | |
| SCHEMBL10003407 | 0.78 | HTT (0.44) | HTTDHODHFGFR1FGFR2FGFR3 | |
| SCHEMBL25112470 | 0.77 | PARP1 (0.54) | MAPTKDM4EHPGDALDH1A1PARP1 | |
| SCHEMBL10282307 | 0.76 | EIF4A3 (0.44) | HTTDHODHFGFR1FGFR2FGFR3 | |
| SCHEMBL24463056 | 0.76 | HTT (0.43) | HTTDHODHCSNK2A1MAPTKDM4E | |
| SCHEMBL25105571 | 0.73 | HTT (0.40) | HTTDHODHFGFR1FGFR2FGFR3 | |
| SCHEMBL12664024 | 0.69 | DHODH (0.40) | HTTDHODHFGFR1FGFR2FGFR3 | |
| SCHEMBL1902643 | 0.69 | PARP1 (0.53) | HTTDHODHKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012083170-A1 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012083164-A1 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-06-21 | — | — | WO | disclosed |
| EP-2455376-A1 | Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2010144646-A2 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2010-12-16 | — | — | WO | disclosed |