Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.53 |
| ▸ | RAF1 | P04049 | 8/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ARAF | P10398 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347333 | 0.86 | LRRK2 (0.67) | LRRK2RAF1NTRK1PIK3C3CCNA2 | |
| SCHEMBL8347330 | 0.86 | LRRK2 (0.67) | LRRK2RAF1NTRK1PIK3C3CCNA2 | |
| SCHEMBL5775715 | 0.83 | LRRK2 (0.76) | LRRK2RAF1NTRK1PIK3C3MAP1LC3B | |
| SCHEMBL8348291 | 0.80 | RAF1 (0.51) | LRRK2RAF1NTRK1PIK3C3CCNA2 | |
| SCHEMBL8348293 | 0.80 | RAF1 (0.51) | LRRK2RAF1NTRK1PIK3C3CCNA2 | |
| SCHEMBL8582684 | 0.79 | RAF1 (0.69) | LRRK2RAF1NTRK1PIK3C3CCNA2 | |
| SCHEMBL8582702 | 0.79 | RAF1 (0.69) | LRRK2RAF1NTRK1PIK3C3CCNA2 | |
| SCHEMBL8346041 | 0.78 | RAF1 (0.52) | LRRK2RAF1NTRK1PIK3C3CCNA2 | |
| SCHEMBL14040856 | 0.78 | RAF1 (0.52) | LRRK2RAF1NTRK1PIK3C3CCNA2 | |
| SCHEMBL8346037 | 0.78 | RAF1 (0.52) | LRRK2RAF1NTRK1PIK3C3CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999021859-A1 | AZAOXINDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-05-06 | — | — | WO | disclosed |