Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.75 |
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | HTR2C | P28335 | 10/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8525623 | 0.89 | HTR2A (0.80) | HTR2AKCNH2DRD2HTR2C | |
| SCHEMBL8523771 | 0.86 | HTR2A (1.00) | HTR2AKCNH2DRD2HTR2C | |
| SCHEMBL8525587 | 0.84 | HTR2A (0.83) | HTR2AKCNH2DRD2HTR2C | |
| SCHEMBL8524470 | 0.82 | HTR2A (0.80) | HTR2AKCNH2DRD2HTR2C | |
| SCHEMBL8524286 | 0.77 | HTR2A (1.00) | HTR2AKCNH2DRD2HTR2C | |
| SCHEMBL8523885 | 0.76 | HTR2A (1.00) | HTR2AKCNH2DRD2HTR2C | |
| SCHEMBL8524319 | 0.74 | HTR2A (1.00) | HTR2AKCNH2DRD2HTR2C | |
| SCHEMBL8524501 | 0.73 | HTR2A (0.85) | HTR2AKCNH2DRD2HTR2C | |
| SCHEMBL8524964 | 0.72 | HTR2A (1.00) | HTR2AKCNH2DRD2HTR2C | |
| SCHEMBL8524469 | 0.72 | HTR2A (1.00) | HTR2AKCNH2DRD2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999047511-A1 | INDOLE DERIVATIVES AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-23 | — | — | WO | claimed |
| WO-1999047511-A1 | INDOLE DERIVATIVES AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-23 | — | — | WO | disclosed |