Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.44 |
| ▸ | SCN7A | Q01118 | 8/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8576686 | 0.85 | SCN9A (0.45) | SCN9ASCN10AKCNH2SCN7ASCN5A | |
| SCHEMBL8545011 | 0.85 | JAK2 (0.43) | SCN9ASCN10AKCNH2SCN7ASCN5A | |
| SCHEMBL8531540 | 0.85 | SCN9A (0.42) | SCN9ASCN10AKCNH2SCN7ASCN5A | |
| SCHEMBL8521244 | 0.79 | SCN9A (0.49) | SCN9ASCN10AKCNH2SCN7ASCN5A | |
| SCHEMBL8543478 | 0.77 | SCN9A (0.43) | SCN9ASCN10AKCNH2SCN7ASCN5A | |
| SCHEMBL8531218 | 0.72 | SCN9A (0.46) | SCN9ASCN10AKCNH2SCN7ASCN5A | |
| SCHEMBL8575105 | 0.71 | SCN9A (0.43) | SCN9ASCN10AKCNH2SCN7ASCN5A | |
| SCHEMBL8532594 | 0.71 | SCN9A (0.44) | SCN9ASCN10AKCNH2SCN7ASCN5A | |
| SCHEMBL32686363 | 0.70 | MAPT (0.40) | LOXL2 | |
| SCHEMBL8541776 | 0.68 | JAK2 (0.43) | SCN9ASCN10AKCNH2SCN7ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012068450-A1 | CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION (US) | 2012-05-24 | — | — | WO | disclosed |