Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.58 |
| ▸ | AURKA | O14965 | 7/20 | 0.58 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764027 | 0.81 | KDR (0.56) | EGFRSRCERBB2KDR | |
| SCHEMBL7235485 | 0.80 | EGFR (0.62) | EGFRAURKBAURKASRCERBB2 | |
| SCHEMBL12694372 | 0.79 | AURKA (0.74) | EGFRAURKBAURKASRCKDR | |
| SCHEMBL7235478 | 0.79 | EGFR (0.61) | EGFRAURKBAURKASRCERBB2 | |
| SCHEMBL8525841 | 0.78 | EGFR (0.61) | EGFRAURKBAURKASRCERBB2 | |
| SCHEMBL7237234 | 0.78 | EGFR (0.72) | EGFRAURKBAURKASRCERBB2 | |
| SCHEMBL7243665 | 0.76 | EGFR (0.60) | EGFRAURKBAURKASRCERBB2 | |
| SCHEMBL8361805 | 0.76 | AURKB (0.61) | EGFRAURKBAURKAERBB2CHEK2 | |
| SCHEMBL7242380 | 0.74 | EGFR (0.59) | EGFRAURKBAURKASRCERBB2 | |
| SCHEMBL7242049 | 0.74 | EGFR (0.61) | EGFRAURKBAURKASRCERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |