Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.62 |
| ▸ | SRC | P12931 | 3/20 | 0.61 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.61 |
| ▸ | LCK | P06239 | 2/20 | 0.61 |
| ▸ | FYN | P06241 | 2/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | MET | P08581 | 2/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.61 |
| ▸ | LTK | P29376 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.61 |
| ▸ | BTK | Q06187 | 2/20 | 0.61 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.61 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237234 | 0.92 | EGFR (0.72) | EGFRERBB2SRCKITERBB3 | |
| SCHEMBL7236143 | 0.90 | EGFR (0.75) | EGFRERBB2SRCKITERBB3 | |
| SCHEMBL7243958 | 0.89 | EGFR (0.71) | EGFRERBB2ERBB4KDR | |
| SCHEMBL23450870 | 0.87 | EGFR (0.70) | EGFRERBB2SRCKITERBB3 | |
| SCHEMBL7242679 | 0.87 | EGFR (0.74) | EGFRERBB2ERBB4KDRJAK3 | |
| SCHEMBL7233730 | 0.84 | EGFR (0.73) | EGFRERBB2SRCKITERBB3 | |
| SCHEMBL24751920 | 0.83 | EGFR (0.65) | EGFRERBB2SRCKITERBB3 | |
| SCHEMBL8525841 | 0.81 | EGFR (0.61) | EGFRERBB2SRCKITERBB3 | |
| SCHEMBL23451101 | 0.81 | EGFR (0.73) | EGFRERBB2SRCKITERBB3 | |
| SCHEMBL23450802 | 0.81 | EGFR (0.65) | EGFRERBB2SRCKITERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006378-A1 | IRREVERSIBLE INHIBITORS OF TYROSINE KINASES | WARNER-LAMBERT COMPANY (US) | 1999-02-11 | — | — | WO | claimed |