Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.48 |
| ▸ | PLK4 | O00444 | 3/20 | 0.47 |
| ▸ | PLK1 | P53350 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8526924 | 0.88 | PDPK1 (0.60) | KDM4EALDH1A1GAAMAPTLRRK2 | |
| SCHEMBL5474945 | 0.82 | MAPT (0.68) | KDM4EALDH1A1GAAMAPTPLK4 | |
| SCHEMBL5474941 | 0.82 | MAPT (0.68) | KDM4EALDH1A1GAAMAPTPLK4 | |
| SCHEMBL5472246 | 0.81 | LRRK2 (0.73) | KDM4EALDH1A1GAAMAPTLRRK2 | |
| SCHEMBL5472244 | 0.81 | LRRK2 (0.73) | KDM4EALDH1A1GAAMAPTLRRK2 | |
| SCHEMBL8528685 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1GAAMAPTLRRK2 | |
| SCHEMBL8527809 | 0.80 | KDM4E (0.54) | KDM4EALDH1A1GAAMAPTLRRK2 | |
| SCHEMBL8530317 | 0.78 | MAPT (0.47) | KDM4EALDH1A1GAAMAPTLRRK2 | |
| SCHEMBL8529701 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1GAAMAPTLRRK2 | |
| Hydrochloric Acid SCHEMBL8526637 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1GAAMAPTLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | claimed |
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | claimed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | claimed |
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | disclosed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |