Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.79 |
| ▸ | HTR2A | P28223 | 16/20 | 0.79 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527704 | 0.89 | HTR2C (1.00) | HTR2CHTR2AHTR2B | |
| SCHEMBL8527702 | 0.83 | HTR2C (0.80) | HTR2CHTR2AHTR2B | |
| SCHEMBL8526785 | 0.83 | HTR2C (0.80) | HTR2CHTR2AHTR2B | |
| SCHEMBL8527508 | 0.83 | HTR2C (1.00) | HTR2CHTR2AHTR2B | |
| SCHEMBL8529842 | 0.82 | HTR2C (0.72) | HTR2CHTR2A | |
| SCHEMBL8529483 | 0.81 | HTR2C (0.76) | HTR2CHTR2A | |
| SCHEMBL8526274 | 0.81 | HTR2C (0.76) | HTR2CHTR2A | |
| SCHEMBL7417766 | 0.80 | HTR2C (0.71) | HTR2CHTR2A | |
| SCHEMBL8529839 | 0.80 | HTR2C (1.00) | HTR2CHTR2A | |
| SCHEMBL8529224 | 0.80 | HTR2C (1.00) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834494-A | SEROTONIN 5HT2B/2C RECEPTOR ANTAGONISTS; CNS NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; IRRITABLE BOWEL SYNDROME | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | claimed |
| EP-0707581-B1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-26 | — | — | EP | claimed |
| US-5834494-A | SEROTONIN 5HT2B/2C RECEPTOR ANTAGONISTS; CNS NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; IRRITABLE BOWEL SYNDROME | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | disclosed |
| EP-0707581-B1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-26 | — | — | EP | disclosed |