SCHEMBL8527147

SCHEMBL8527147

CC(COC(=O)c1ccccc1)(C(=O)O)C(=O)O

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.72
HIF1A Q16665 1/20 0.72
TDP1 Q9NUW8 5/20 0.58
SLC6A3 Q01959 2/20 0.58
HTR1A P08908 1/20 0.58
CYP2D6 P10635 1/20 0.58
SCN1A P35498 1/20 0.58
SCN5A Q14524 1/20 0.58
SCN2A Q99250 1/20 0.58
SCN3A Q9NY46 1/20 0.58
LMNA P02545 2/20 0.55
ALDH1A1 P00352 4/20 0.54
KMT2A Q03164 2/20 0.54
SLC6A2 P23975 1/20 0.52
TSHR P16473 3/20 0.51
ADRB2 P07550 1/20 0.50
ADRB1 P08588 1/20 0.50
ADRB3 P13945 1/20 0.50
HSD17B10 Q99714 1/20 0.50
RAB9A P51151 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9888201 0.85 MAPK1 (0.67) MAPK1HIF1ATDP1SLC6A3HTR1A
SCHEMBL204567 0.85 MAPK1 (0.71) MAPK1HIF1ATDP1SLC6A3HTR1A
SCHEMBL2020359 0.85 MAPK1 (0.71) MAPK1HIF1ATDP1SLC6A3HTR1A
SCHEMBL444012 0.85 MAPK1 (0.71) MAPK1HIF1ATDP1SLC6A3HTR1A
SCHEMBL27620 0.84 MAPK1 (1.00) MAPK1HIF1ATDP1SLC6A3HTR1A
SCHEMBL7287259 0.83 MAPK1 (0.69) MAPK1HIF1ATDP1SLC6A3HTR1A
SCHEMBL27559017 0.83 MAPK1 (0.69) MAPK1HIF1ATDP1SLC6A3HTR1A
SCHEMBL4578066 0.83 MAPK1 (0.69) MAPK1HIF1ATDP1SLC6A3HTR1A
SCHEMBL8258980 0.81 MAPK1 (0.67) MAPK1HIF1ATDP1SLC6A3HTR1A
SCHEMBL5401304 0.81 MAPK1 (0.67) MAPK1HIF1ATDP1SLC6A3HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5736523-A ADMINISTERING TO THE MAMMAL SUFFERING FROM CANCER BIOCHEM PHARMA INC. (CA) 1998-04-07 US disclosed
US-5606037-A Processes antineoplastic heteronaphthoquinones BIOCHEM PHARMA INC. (CA) 1997-02-25 US disclosed
EP-0659190-A1 ANTINEOPLASTIC HETERONAPHTHOQUINONES BIOCHEM PHARMA INC (CA) 1995-06-28 EP disclosed
WO-1994011382-A1 ANTINEOPLASTIC HETERONAPHTHOQUINONES BIOCHEM PHARMA INC. (CA) 1994-05-26 WO disclosed