Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.65 |
| ▸ | TSHR | P16473 | 6/20 | 0.65 |
| ▸ | CTSL | P07711 | 1/20 | 0.59 |
| ▸ | CTSS | P25774 | 1/20 | 0.59 |
| ▸ | CTSK | P43235 | 2/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21469067 | 1.00 | ATM (0.68) | ATMCYP3A4TSHRCTSLCTSS | |
| SCHEMBL30460502 | 1.00 | ATM (0.68) | ATMCYP3A4TSHRCTSLCTSS | |
| SCHEMBL13721922 | 0.92 | ATM (0.63) | ATMCYP3A4TSHRCTSLCTSS | |
| SCHEMBL18459501 | 0.92 | ATM (0.63) | ATMCYP3A4TSHRCTSLCTSS | |
| SCHEMBL13721804 | 0.92 | ATM (0.63) | ATMCYP3A4TSHRCTSLCTSS | |
| SCHEMBL4444864 | 0.90 | ATM (0.60) | ATMCYP3A4TSHRCTSLCTSS | |
| SCHEMBL21399863 | 0.90 | ATM (0.60) | ATMCYP3A4TSHRCTSLCTSS | |
| SCHEMBL2851560 | 0.90 | ATM (0.60) | ATMCYP3A4TSHRCTSLCTSS | |
| SCHEMBL12951666 | 0.90 | ATM (0.60) | ATMCYP3A4TSHRCTSLCTSS | |
| SCHEMBL21404926 | 0.90 | ATM (0.60) | ATMCYP3A4TSHRCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013812-B1 | KAPPA OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS (US) | 2019-10-16 | — | — | EP | disclosed |
| US-7449447-B2 | Peptidomimetic NS3-serine protease inhibitors of hepatitis C virus | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-5807875-A | OBESITY THERAPY | DR. KARL THOMAE GMBH (DE) | 1998-09-15 | — | — | US | disclosed |