Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 5/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.58 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.55 |
| ▸ | FCER2 | P06734 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8527809 | 0.88 | KDM4E (0.54) | PDPK1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL5182059 | 0.83 | PDPK1 (0.60) | PDPK1SYKNTRK1NTRK3NTRK2 | |
| SCHEMBL5182063 | 0.83 | PDPK1 (0.60) | PDPK1SYKNTRK1NTRK3NTRK2 | |
| SCHEMBL5474941 | 0.81 | MAPT (0.68) | KDM4EALDH1A1GAAMAPTKDR | |
| SCHEMBL5474945 | 0.81 | MAPT (0.68) | KDM4EALDH1A1GAAMAPTKDR | |
| SCHEMBL5472246 | 0.80 | LRRK2 (0.73) | KDM4EALDH1A1GAAMAPTPDGFRB | |
| SCHEMBL5472244 | 0.80 | LRRK2 (0.73) | KDM4EALDH1A1GAAMAPTPDGFRB | |
| SCHEMBL8526924 | 0.80 | PDPK1 (0.60) | PDPK1KDM4EALDH1A1GAAMAPT | |
| SCHEMBL6394720 | 0.79 | PDPK1 (0.65) | PDPK1SYKNTRK1NTRK3NTRK2 | |
| SCHEMBL6394717 | 0.79 | PDPK1 (0.65) | PDPK1SYKNTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | claimed |
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | claimed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | claimed |
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | disclosed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |