Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15379631 | 0.88 | TAAR1 (0.58) | TAAR1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12809089 | 0.87 | TSHR (0.48) | TAAR1LMNAHPGDRAB9ANPC1 | |
| SCHEMBL721007 | 0.82 | TAAR1 (0.56) | TAAR1LMNAHPGDRAB9ANPC1 | |
| SCHEMBL28985382 | 0.80 | TAAR1 (0.54) | TAAR1LMNAHPGDRAB9ANPC1 | |
| SCHEMBL198134 | 0.79 | TSHR (0.52) | TAAR1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8905819 | 0.79 | TAAR1 (0.48) | TAAR1RAB9ANPC1SMN1; SMN2POLB | |
| SCHEMBL8905812 | 0.79 | TAAR1 (0.48) | TAAR1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12064579 | 0.79 | TAAR1 (0.48) | TAAR1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6333918 | 0.79 | TAAR1 (0.57) | TAAR1LMNAHPGDRAB9ANPC1 | |
| SCHEMBL8921330 | 0.79 | TAAR1 (0.57) | TAAR1LMNAHPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649418-B1 | 7-(2-AMINOETHYL)-BENZOTHIAZOLONES | ASTRA PHARMA PROD (GB) | 1998-10-28 | — | — | EP | disclosed |
| US-5648370-A | 7-(2-aminoethyl) benzothiazolones | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-07-15 | — | — | US | disclosed |
| EP-0649418-A1 | 7-(2-AMINOETHYL)-BENZOTHIAZOLONES | Astra Pharmaceuticals Limited (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993024473-A1 | 7-(2-AMINOETHYL)-BENZOTHIAZOLONES | FISONS PLC (GB) | 1993-12-09 | — | — | WO | disclosed |