Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8533053 | 0.95 | DHODH (0.46) | DHODHALDH1A1HSD17B10MAPTTACR3 | |
| SCHEMBL8531978 | 0.91 | MCL1 (0.45) | ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8532864 | 0.91 | CYP1A2 (0.40) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL8533380 | 0.90 | CYP2C9 (0.42) | ALDH1A1MAPTNPC1L3MBTL1RAB9A | |
| SCHEMBL8531280 | 0.85 | MCL1 (0.46) | ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8528989 | 0.85 | CYP1A2 (0.41) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL8532755 | 0.85 | CYP1A2 (0.43) | ALDH1A1HSD17B10MAPTNPC1L3MBTL1 | |
| SCHEMBL8797564 | 0.83 | MCL1 (0.46) | MAPTKMT2ASMN1; SMN2FFAR1 | |
| SCHEMBL8796844 | 0.83 | POLB (0.43) | MAPTNPC1RAB9ASMN1; SMN2FFAR1 | |
| SCHEMBL8530656 | 0.79 | MAPT (0.42) | ALDH1A1MAPTTACR3KMT2AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066150-C | Bridged indoles as matrix metalloprotease inhibitors | SYNTEX INC (US) | 2001-05-23 | — | — | CN | disclosed |
| US-5773428-A | BONE DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1998-06-30 | — | — | US | disclosed |
| CN-1180358-A | Bridged indoles as matrix metalloprotease inhibitors | SYNTEX INC (US) | 1998-04-29 | — | — | CN | disclosed |
| WO-1996023791-A1 | BRIDGED INDOLES AS MATRIX METALLOPROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-08-08 | — | — | WO | disclosed |