Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.32 |
| ▸ | PARP16 | Q8N5Y8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805762 | 1.00 | CDK5 (0.37) | CDK5CDK5R1ANPEPDPP4HSD17B1 | |
| SCHEMBL861378 | 1.00 | CDK5 (0.37) | CDK5CDK5R1ANPEPDPP4HSD17B1 | |
| SCHEMBL2598004 | 0.85 | PARP1 (0.39) | MAPK1MEN1KMT2APARP1SLC6A2 | |
| SCHEMBL860850 | 0.85 | PARP1 (0.39) | MAPK1MEN1KMT2APARP1SLC6A2 | |
| SCHEMBL860851 | 0.85 | PARP1 (0.39) | MAPK1MEN1KMT2APARP1SLC6A2 | |
| SCHEMBL2598003 | 0.85 | PARP1 (0.39) | MAPK1MEN1KMT2APARP1SLC6A2 | |
| SCHEMBL1808782 | 0.84 | CA12 (0.37) | ANPEPDPP4PARP3KMT2ANR1H2 | |
| SCHEMBL2598123 | 0.84 | KMT2A (0.41) | DPP4LMNAMEN1KMT2APARP1 | |
| SCHEMBL2598124 | 0.84 | KMT2A (0.41) | DPP4LMNAMEN1KMT2APARP1 | |
| SCHEMBL860523 | 0.84 | KMT2A (0.41) | DPP4LMNAMEN1KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| EP-2432783-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2010135560-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-11-25 | — | — | WO | disclosed |