Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538197 | 0.76 | SLC6A2 (0.61) | SLC6A2NPC1 | |
| SCHEMBL937306 | 0.74 | NPC1 (0.44) | SLC6A2NPC1FGFR4 | |
| SCHEMBL9685872 | 0.71 | NPC1 (0.39) | SLC6A2NPC1FGFR4 | |
| SCHEMBL8537904 | 0.69 | SLC6A2 (0.40) | SLC6A2 | |
| SCHEMBL5883439 | 0.68 | POLB (0.46) | SLC6A2NPC1 | |
| SCHEMBL414257 | 0.68 | CSF1R (0.48) | SLC6A2NPC1 | |
| SCHEMBL16665315 | 0.67 | FGFR4 (0.37) | SLC6A2NPC1FGFR4 | |
| SCHEMBL601169 | 0.67 | SLC6A2 (0.37) | SLC6A2NPC1 | |
| SCHEMBL17369262 | 0.66 | SLC6A2 (0.35) | SLC6A2NPC1FGFR4 | |
| SCHEMBL4874968 | 0.66 | LRRK2 (0.42) | SLC6A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417584-B1 | N-substituted-4-pyrimidinamines and -pyrimidindiamines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-02-04 | — | — | EP | claimed |
| US-4983608-A | Analgesics, cognition activators | HOECHST-ROUSSELL PHARMACEUTICALS, INC. (US) | 1991-01-08 | — | — | US | claimed |
| EP-0417584-B1 | N-substituted-4-pyrimidinamines and -pyrimidindiamines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-02-04 | — | — | EP | disclosed |
| US-5179204-A | Learning enhancement, analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-12 | — | — | US | disclosed |
| EP-0417584-A2 | N-substituted-4-pyrimidinamines and -pyrimidindiamines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4983608-A | Analgesics, cognition activators | HOECHST-ROUSSELL PHARMACEUTICALS, INC. (US) | 1991-01-08 | — | — | US | disclosed |