Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.46 |
| ▸ | CDK8 | P49336 | 4/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1599862 | 0.89 | MAPK14 (0.47) | MAPK14CDK8CSNK1A1SLC22A12 | |
| SCHEMBL8536925 | 0.84 | MAPK14 (0.47) | MAPK14SCARB1 | |
| SCHEMBL1600569 | 0.78 | MAPK14 (0.64) | MAPK14SCARB1 | |
| SCHEMBL1600554 | 0.78 | MAPK14 (0.57) | MAPK14SCARB1 | |
| SCHEMBL8534468 | 0.77 | MAPK14 (0.41) | MAPK14SCARB1MAPK9 | |
| SCHEMBL1600583 | 0.77 | MAPK14 (0.49) | MAPK14 | |
| SCHEMBL5823307 | 0.75 | MAPK14 (0.36) | MAPK14SLC22A12 | |
| SCHEMBL4411181 | 0.75 | MAPK14 (0.44) | MAPK14MAPK9 | |
| SCHEMBL1598842 | 0.74 | MAPK14 (0.81) | MAPK14SCARB1 | |
| SCHEMBL1600460 | 0.73 | MAPK14 (0.47) | MAPK14SCARB1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670787-B1 | CYTOKINE INHIBITORS | ITHERX PHARMA INC (US) | 2012-05-30 | — | — | EP | claimed |