Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 8/20 | 0.39 |
| ▸ | MAOA | P21397 | 7/20 | 0.39 |
| ▸ | KDM1A | O60341 | 5/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188987 | 1.00 | TP53 (0.49) | TP53MDM2DDB1CRBNGAA | |
| SCHEMBL8537684 | 1.00 | TP53 (0.49) | TP53MDM2DDB1CRBNGAA | |
| SCHEMBL2188979 | 1.00 | TP53 (0.49) | TP53MDM2DDB1CRBNGAA | |
| SCHEMBL2188994 | 1.00 | TP53 (0.49) | TP53MDM2DDB1CRBNGAA | |
| Hydrochloric Acid SCHEMBL6818558 | 0.98 | TP53 (0.48) | TP53MDM2DDB1CRBNGAA | |
| SCHEMBL8631315 | 0.83 | TDP1 (0.45) | TP53MDM2DDB1CRBNSMN1; SMN2 | |
| SCHEMBL2189767 | 0.83 | TP53 (0.43) | TP53MDM2DDB1CRBNGAA | |
| SCHEMBL2189775 | 0.83 | TP53 (0.43) | TP53MDM2DDB1CRBNGAA | |
| SCHEMBL2189771 | 0.83 | TP53 (0.43) | TP53MDM2DDB1CRBNGAA | |
| SCHEMBL2190043 | 0.83 | TP53 (0.43) | TP53MDM2DDB1CRBNGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594636-B1 | 3-AMINOPIPERIDINE DERIVATIVES AND RELATED NITROGEN CONTAINING HETEROCYCLES | PFIZER (US) | 1998-01-21 | — | — | EP | disclosed |
| EP-0436334-B1 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5332817-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1994-07-26 | — | — | US | disclosed |
| EP-0594636-A1 | 3-AMINOPIPERIDINE DERIVATIVES AND RELATED NITROGEN CONTAINING HETEROCYCLES | PFIZER INC. (US) | 1994-05-04 | — | — | EP | disclosed |
| US-5232929-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1993001170-A1 | 3-AMINOPIPERIDINE DERIVATIVES AND RELATED NITROGEN CONTAINING HETEROCYCLES | PFIZER INC. (US) | 1993-01-21 | — | — | WO | disclosed |
| WO-1991009844-A1 | SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1991-07-11 | — | — | WO | disclosed |
| EP-0436334-A2 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |