Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.46 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | CTSD | P07339 | 6/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538718 | 1.00 | BACE1 (0.46) | BACE1CTSBCTSDBACE2 | |
| SCHEMBL9932194 | 0.87 | BACE1 (0.47) | BACE1CTSBCTSDBACE2 | |
| SCHEMBL9932066 | 0.82 | BACE1 (0.44) | BACE1CTSBCTSDBACE2 | |
| SCHEMBL10238054 | 0.81 | BACE1 (0.56) | BACE1CTSBCTSD | |
| SCHEMBL9882480 | 0.81 | BACE1 (0.56) | BACE1CTSBCTSD | |
| SCHEMBL9931896 | 0.81 | BACE1 (0.56) | BACE1CTSBCTSD | |
| SCHEMBL9931899 | 0.81 | BACE1 (0.56) | BACE1CTSBCTSD | |
| SCHEMBL9882441 | 0.81 | BACE1 (0.56) | BACE1CTSBCTSD | |
| SCHEMBL8537151 | 0.80 | BACE1 (0.55) | BACE1CTSBCTSD | |
| SCHEMBL8532624 | 0.80 | BACE1 (0.55) | BACE1CTSBCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012071458-A1 | HETEROCYCLIC INHIBITORS OF BETA - SECRETASE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2012-05-31 | — | — | WO | disclosed |