Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 20/20 | 1.00 |
| ▸ | STAT5B | P51692 | 5/20 | 0.85 |
| ▸ | STAT1 | P42224 | 4/20 | 0.81 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.65 |
| ▸ | PTPRS | Q13332 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15207542 | 0.92 | STAT3 (1.00) | STAT3STAT5BSTAT1PTPN2PTPN1 | |
| SCHEMBL10246024 | 0.92 | STAT3 (0.91) | STAT3STAT5BSTAT1 | |
| SCHEMBL15208150 | 0.91 | STAT3 (0.83) | STAT3STAT5BSTAT1PTPN2PTPN1 | |
| SCHEMBL15215011 | 0.90 | STAT3 (0.88) | STAT3STAT5BSTAT1 | |
| SCHEMBL15215032 | 0.90 | STAT3 (1.00) | STAT3STAT5BSTAT1PTPN2PTPN1 | |
| SCHEMBL8282961 | 0.90 | STAT3 (0.82) | STAT3STAT5BSTAT1 | |
| SCHEMBL10246169 | 0.90 | STAT3 (0.87) | STAT3STAT5BSTAT1 | |
| SCHEMBL10246419 | 0.88 | STAT3 (0.90) | STAT3STAT5BSTAT1PTPN2PTPN1 | |
| SCHEMBL15207855 | 0.88 | STAT3 (1.00) | STAT3STAT5BSTAT1PTPN2PTPN1 | |
| SCHEMBL15215031 | 0.87 | STAT3 (0.77) | STAT3STAT5BSTAT1PTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895746-B2 | Compounds that suppress cancer cells and exhibit antitumor activity | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20140194468-A1 | Compounds that Suppress Cancer Cells and Exhibit Antitumor Activity | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2014-07-10 | — | — | US | disclosed |
| US-8586749-B2 | Compounds that suppress cancer cells and exhibit antitumor activity | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-20120130079-A1 | Compounds That Suppress Cancer Cells and Exhibit Antitumor Activity | UNIVERSITY OF TORONTO MISSISSAUGA (CA) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120130079-A1 | Compounds That Suppress Cancer Cells and Exhibit Antitumor Activity | STAT3, STAT1, STAT6 | STAT3 1/4885STAT5B 5/4885STAT1 2/4885 |
| US-20140194468-A1 | Compounds that Suppress Cancer Cells and Exhibit Antitumor Activity | STAT3, STAT1, STAT6 | STAT3 1/4885STAT5B 5/4885STAT1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.