Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538382 | 0.92 | MAPK8 (0.42) | MDM2MAPK8MAPK9 | |
| SCHEMBL8545338 | 0.91 | MDM2 (0.49) | MDM2MAPK8MAPK9 | |
| SCHEMBL8544317 | 0.91 | MAPK8 (0.44) | MDM2MAPK8MAPK9 | |
| SCHEMBL8543479 | 0.83 | MDM2 (0.43) | MDM2MAPK8IDO1MAPK9 | |
| SCHEMBL8539840 | 0.81 | MAPK8 (0.41) | MDM2MAPK8IDO1ALDH1A1 | |
| SCHEMBL8544976 | 0.79 | MDM2 (0.45) | MDM2ALDH1A1 | |
| SCHEMBL8546091 | 0.79 | MDM2 (0.42) | MDM2IDO1KDM4EALDH1A1 | |
| SCHEMBL8546995 | 0.75 | MAPK8 (0.43) | MDM2MAPK8MAPK9 | |
| SCHEMBL8540705 | 0.74 | MDM2 (0.45) | MDM2KDM4EALDH1A1 | |
| SCHEMBL8538384 | 0.74 | MAPK8 (0.42) | MDM2MAPK8ALDH1A1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483881-B1 | 3-Amidoindolyl derivatives | MERRELL PHARMA INC (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5703107-A | CENTRAL NERVOUS SYSTEM DISORDERS; ANALGESICS; ANTIEPILEPTIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5675018-A | 3-amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5491153-A | 3-amidoindolyl derivative | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5189054-A | 3-amidoindolyl derivatives and pharmaceutical compositions thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0483881-A1 | 3-Amidoindolyl derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-05-06 | — | — | EP | disclosed |