Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.56 |
| ▸ | CTSS | P25774 | 3/20 | 0.54 |
| ▸ | CTSK | P43235 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | REN | P00797 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269627 | 1.00 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7270592 | 0.92 | KLK5 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9848360 | 0.92 | KLK5 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6446193 | 0.90 | KLK5 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8534875 | 0.90 | KLK5 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6444857 | 0.90 | KLK5 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6446777 | 0.90 | KLK5 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6445320 | 0.90 | KLK5 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8532202 | 0.90 | KLK5 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6445261 | 0.90 | KLK5 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |