Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542135 | 0.89 | MDM2 (0.45) | NR1H2MDM2P2RY12AURKAAURKB | |
| SCHEMBL8540513 | 0.84 | MDM2 (0.48) | NR1H2MDM2KMT2ALMNAKDM4E | |
| SCHEMBL8538967 | 0.82 | MDM2 (0.44) | NR1H2MDM2KMT2ALMNAKDM4E | |
| SCHEMBL8542139 | 0.82 | MDM2 (0.45) | NR1H2MDM2LMNAALDH1A1P2RY12 | |
| SCHEMBL8541912 | 0.81 | MDM2 (0.45) | NR1H2MDM2KMT2ALMNAKDM4E | |
| SCHEMBL8541910 | 0.81 | MDM2 (0.43) | NR1H2MDM2KMT2AKDM4EALDH1A1 | |
| SCHEMBL8541127 | 0.80 | MDM2 (0.44) | NR1H2MDM2KMT2ALMNAKDM4E | |
| SCHEMBL8540675 | 0.80 | MDM2 (0.46) | MDM2KMT2ATSHRLMNAKDM4E | |
| SCHEMBL8545119 | 0.80 | MDM2 (0.41) | MDM2LMNAALDH1A1TP53 | |
| SCHEMBL8546220 | 0.79 | MDM2 (0.43) | NR1H2MDM2KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483881-B1 | 3-Amidoindolyl derivatives | MERRELL PHARMA INC (US) | 1998-01-21 | — | — | EP | disclosed |