Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.72 |
| ▸ | EDNRB | P24530 | 17/20 | 0.72 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856895 | 0.95 | EDNRB (0.71) | EDNRAEDNRB | |
| SCHEMBL8590639 | 0.95 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL8856638 | 0.94 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL8856815 | 0.94 | EDNRB (0.74) | EDNRAEDNRB | |
| SCHEMBL8856820 | 0.94 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL8856631 | 0.92 | EDNRB (0.65) | EDNRAEDNRB | |
| SCHEMBL8856822 | 0.92 | EDNRA (0.70) | EDNRAEDNRB | |
| SCHEMBL8856577 | 0.92 | EDNRB (0.64) | EDNRAEDNRBS1PR1S1PR5 | |
| SCHEMBL8856755 | 0.92 | EDNRB (0.65) | EDNRAEDNRB | |
| SCHEMBL8857076 | 0.92 | EDNRB (0.64) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800389-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5684032-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC, ANTIASTHMATIC AGENTS AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0800389-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996018393-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-20 | — | — | WO | disclosed |