Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 3/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | BUB1 | O43683 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548736 | 0.89 | FGFR2 (0.55) | FGFR2FLT3MAOAMAOBEGFR | |
| SCHEMBL8543878 | 0.81 | MAPKAPK2 (0.56) | EGFRKDR | |
| SCHEMBL8544057 | 0.78 | EGFR (0.48) | MAOAMAOBEGFRFLT1SYK | |
| SCHEMBL8547284 | 0.78 | GAA (0.39) | FGFR2FLT3SYKMAPK14ULK1 | |
| SCHEMBL2975973 | 0.78 | PRKCQ (0.55) | FGFR2FLT3MAOAMAOBEGFR | |
| SCHEMBL8542362 | 0.78 | EGFR (0.48) | FGFR2FLT3MAOAMAOBEGFR | |
| SCHEMBL8549215 | 0.77 | PRKCQ (0.41) | FGFR2FLT3MAPK14ULK1PRKCQ | |
| SCHEMBL11948704 | 0.77 | FGFR2 (0.56) | FGFR2FLT3MAOAMAOBEGFR | |
| SCHEMBL8791496 | 0.77 | FGFR2 (0.56) | FGFR2FLT3MAOAMAOBEGFR | |
| SCHEMBL19781514 | 0.76 | AHR (0.56) | FGFR2FLT3MAOAMAOBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0405425-B1 | Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-08-12 | — | — | EP | claimed |
| EP-0405425-A2 | Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | claimed |
| US-4970219-A | TOPICAL ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-11-13 | — | — | US | claimed |
| EP-0405425-B1 | Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-08-12 | — | — | EP | disclosed |
| US-5405856-A | Skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-04-11 | — | — | US | disclosed |
| US-5221682-A | Skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-06-22 | — | — | US | disclosed |
| US-5034403-A | Topical antiinflammatory agents for skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4983615-A | ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0405425-A2 | Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4970219-A | TOPICAL ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-11-13 | — | — | US | disclosed |