Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543148 | 0.97 | MAPK1 (0.39) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8546726 | 0.94 | MAPK1 (0.36) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8548567 | 0.94 | MAPK1 (0.43) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8544269 | 0.94 | MAPK1 (0.41) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8543037 | 0.91 | MAPK1 (0.41) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8543952 | 0.91 | MAPK1 (0.40) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8588573 | 0.87 | MAPK1 (0.39) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8547641 | 0.87 | MAPK1 (0.44) | MAPK1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL7229034 | 0.87 | MAPK1 (0.39) | MAPK1L3MBTL1GRM2 | |
| SCHEMBL8548492 | 0.85 | MAPK1 (0.39) | MAPK1L3MBTL1MMP1MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |