Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544668 | 1.00 | PTPN1 (0.61) | PTPN1KDRPPARGPPARACYP2C9 | |
| SCHEMBL8544669 | 1.00 | PTPN1 (0.61) | PTPN1KDRPPARGPPARACYP2C9 | |
| SCHEMBL9078794 | 0.94 | PTPN1 (0.60) | PTPN1KDRPPARGPPARACYP2C9 | |
| SCHEMBL9078795 | 0.94 | PTPN1 (0.60) | PTPN1KDRPPARGPPARACYP2C9 | |
| SCHEMBL9078620 | 0.92 | PTPN1 (0.60) | PTPN1KDRPPARGPPARACYP2C9 | |
| SCHEMBL9078622 | 0.92 | PTPN1 (0.60) | PTPN1KDRPPARGPPARACYP2C9 | |
| SCHEMBL9078616 | 0.92 | PTPN1 (0.60) | PTPN1KDRPPARGPPARACYP2C9 | |
| SCHEMBL8546309 | 0.90 | PTPN1 (0.58) | PTPN1KDRPPARGPPARACYP2C9 | |
| SCHEMBL8546314 | 0.90 | PTPN1 (0.58) | PTPN1KDRPPARGPPARACYP2C9 | |
| SCHEMBL8546303 | 0.90 | PTPN1 (0.58) | PTPN1KDRPPARGPPARACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759919-B1 | AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS | AMERICAN HOME PROD (US) | 1998-11-11 | — | — | EP | disclosed |
| US-5532256-A | ORALLY ADMINISTERED ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-02 | — | — | US | disclosed |
| WO-1995031454-A1 | NEW AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-23 | — | — | WO | disclosed |
| US-5468762-A | Antidiabetic agents for administering by mouth | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-21 | — | — | US | disclosed |