SCHEMBL8545154

SCHEMBL8545154

O=c1[nH]c(=O)n(Cc2ccc(Oc3ccc(Cl)c(Oc4ccc(Cn5oc(=O)[nH]c5=O)cc4)c3)cc2)o1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PLAT P00750 8/20 0.46
FFAR1 O14842 2/20 0.41
DAO P14920 2/20 0.38
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
MAOB P27338 1/20 0.35
P2RX3 P56373 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8546217 0.90 PLAT (0.45) PLATFFAR1DAOMEN1KMT2A
SCHEMBL8546551 0.87 FFAR1 (0.46) PLATFFAR1DAOMEN1KMT2A
SCHEMBL8550945 0.87 FFAR1 (0.46) PLATFFAR1DAOMEN1KMT2A
SCHEMBL8547186 0.86 MEN1 (0.43) PLATFFAR1DAOMEN1KMT2A
SCHEMBL8551265 0.85 FFAR1 (0.42) PLATFFAR1DAOMEN1KMT2A
SCHEMBL8544251 0.84 FFAR1 (0.48) PLATFFAR1DAOMEN1KMT2A
SCHEMBL8549206 0.83 FNTA (0.42) PLATFFAR1
SCHEMBL8550204 0.83 PLAT (0.43) PLATFFAR1DAOMEN1KMT2A
SCHEMBL8546158 0.83 PLAT (0.48) PLATFFAR1MEN1KMT2AMAOB
SCHEMBL8547757 0.83 DAO (0.50) PLATFFAR1DAOMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed