Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.70 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | APP | P05067 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | MIF | P14174 | 5/20 | 0.59 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545649 | 1.00 | MAOB (0.70) | MAOBCYP19A1MAPTGAAAPP | |
| SCHEMBL3503220 | 0.93 | MAPT (0.73) | MAOBCYP19A1MAPTGAAAPP | |
| SCHEMBL8541338 | 0.92 | MIF (0.70) | MAOBCYP19A1MAPTGAAAPP | |
| SCHEMBL8541335 | 0.92 | MIF (0.70) | MAOBCYP19A1MAPTGAAAPP | |
| SCHEMBL8543868 | 0.88 | MAPT (0.70) | MAOBCYP19A1MAPTGAASMN1; SMN2 | |
| SCHEMBL8543861 | 0.88 | MAPT (0.70) | MAOBCYP19A1MAPTGAASMN1; SMN2 | |
| SCHEMBL13254636 | 0.88 | MAOB (0.85) | MAOBCYP19A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL3502646 | 0.88 | MAOB (0.85) | MAOBCYP19A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL30832103 | 0.84 | MAOB (0.79) | MAOBCYP19A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL8549423 | 0.83 | MAOB (0.73) | MAOBCYP19A1MAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557075-B1 | 4H-naphtho 1,2-b pyran derivatives as antiproliferative agents | LILLY CO ELI (GB) | 1998-06-24 | — | — | EP | disclosed |
| US-5663375-A | CELL PROLIFERATION | ELI LILLY AND COMPANY (US) | 1997-09-02 | — | — | US | disclosed |
| US-5622987-A | PREVENT MIGRATION OR PROLIFERATION OF SMOOTH MUSCLE CELLS | ELI LILLY AND COMPANY (US) | 1997-04-22 | — | — | US | disclosed |
| US-5378699-A | Treatment of immune diseases, cell proliferation, restenosis and smooth muscle cells | LILLY INDUSTRIES LIMITED (GB) | 1995-01-03 | — | — | US | disclosed |
| US-5378717-A | Therapy for diabetic complications | ELI LILLY AND COMPANY (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0557075-A1 | 4H-naphtho 1,2-b pyran derivatives as antiproliferative agents | LILLY INDUSTRIES LIMITED (GB) | 1993-08-25 | — | — | EP | disclosed |