Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 10/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 9/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 6/20 | 0.41 |
| ▸ | ACHE | P22303 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545980 | 1.00 | HTR1B (0.46) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8913482 | 0.87 | HTR1B (0.53) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8540823 | 0.83 | HTR1B (0.47) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8539366 | 0.83 | HTR1B (0.48) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8539118 | 0.83 | HTR1B (0.48) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8539123 | 0.83 | HTR1B (0.48) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8915066 | 0.81 | HTR1B (0.54) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8790876 | 0.80 | HTR1B (0.48) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8542993 | 0.79 | HTR1B (0.48) | HTR1BHTR1ACHRM2ADRA2ACHRM1 | |
| SCHEMBL8540887 | 0.79 | HTR1B (0.48) | HTR1BHTR1ACHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785933-B1 | INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS | PFIZER LTD (GB) | 1998-03-11 | — | — | EP | claimed |
| EP-0785933-A1 | INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS | Pfizer Limited (GB) | 1997-07-30 | — | — | EP | claimed |
| WO-1996011195-A1 | INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS | PFIZER LIMITED (GB) | 1996-04-18 | — | — | WO | claimed |
| EP-0785933-B1 | INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS | PFIZER LTD (GB) | 1998-03-11 | — | — | EP | disclosed |