Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 9/20 | 0.49 |
| ▸ | HTR1D | P28221 | 6/20 | 0.49 |
| ▸ | HTR1A | P08908 | 5/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 11/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540823 | 0.85 | HTR1B (0.47) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8540735 | 0.80 | HTR1B (0.49) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8541457 | 0.80 | HTR1B (0.49) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8915498 | 0.80 | HTR1B (0.71) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8915066 | 0.78 | HTR1B (0.54) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8915333 | 0.77 | HTR1B (0.54) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8915075 | 0.77 | HTR1B (0.56) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8913482 | 0.76 | HTR1B (0.53) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8887546 | 0.76 | HTR1B (0.59) | HTR1BHTR1DHTR1ACHRM2ADRA2A | |
| SCHEMBL8915023 | 0.75 | HTR1B (0.51) | HTR1BHTR1DHTR1ACHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785933-B1 | INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS | PFIZER LTD (GB) | 1998-03-11 | — | — | EP | disclosed |