SCHEMBL8546305

SCHEMBL8546305

CCCN(c1ccncc1)n1ccc2cc(C(NC(=O)O)c3ccc(Cl)cc3)ccc21

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 15/20 0.65
SLC6A9 P48067 1/20 0.37
PRCP P42785 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8545162 0.93 SLC6A2 (0.57) SLC6A2
SCHEMBL8539048 0.81 SLC6A2 (0.54) SLC6A2
SCHEMBL7608039 0.80 SLC6A2 (1.00) SLC6A2
Maleic Acid SCHEMBL7612075 0.80 SLC6A2 (0.81) SLC6A2
Fumaric Acid SCHEMBL7612082 0.80 SLC6A2 (0.81) SLC6A2
SCHEMBL8539053 0.79 SLC6A2 (0.56) SLC6A2
SCHEMBL8546312 0.79 SLC6A2 (0.69) SLC6A2
SCHEMBL8544343 0.78 SLC6A2 (0.53) SLC6A2
SCHEMBL8545510 0.78 SLC6A2 (0.54) SLC6A2
SCHEMBL8545074 0.77 SLC6A2 (0.60) SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0468401-B1 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process for their preparation and their use as medicaments HOECHST MARION ROUSSEL INC (US) 1998-09-16 EP disclosed
EP-0468401-A2 1-(Substituted pyridinylamino)-1H-indol-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-01-29 EP disclosed