Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 8/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | KIF5B | P33176 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547844 | 1.00 | EGFR (0.58) | EGFRERBB2RETABCG2CLK1 | |
| SCHEMBL7982973 | 0.92 | RET (0.55) | EGFRERBB2RETABCG2CLK1 | |
| SCHEMBL7982971 | 0.92 | RET (0.55) | EGFRERBB2RETABCG2CLK1 | |
| SCHEMBL7978417 | 0.89 | RET (0.60) | EGFRERBB2RETABCG2CLK1 | |
| SCHEMBL7979994 | 0.89 | EGFR (0.63) | EGFRERBB2RETABCG2CLK1 | |
| SCHEMBL7979991 | 0.89 | EGFR (0.63) | EGFRERBB2RETABCG2CLK1 | |
| SCHEMBL7978415 | 0.89 | RET (0.60) | EGFRERBB2RETABCG2CLK1 | |
| SCHEMBL7980425 | 0.88 | RET (0.61) | EGFRERBB2RETABCG2CLK1 | |
| SCHEMBL7980428 | 0.88 | RET (0.61) | EGFRERBB2RETABCG2CLK1 | |
| SCHEMBL7976955 | 0.88 | EGFR (0.59) | EGFRERBB2RETABCG2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |