Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.64 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.62 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.62 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.62 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.62 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.62 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543338 | 0.90 | GRIN1 (0.64) | GRIN2BGRIN1ACHE | |
| SCHEMBL8546768 | 0.88 | GRIN2B (0.61) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4671945 | 0.83 | GRIN2B (0.58) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL8542972 | 0.82 | GRIN2B (0.60) | GRIN2BGRIN1ACHE | |
| SCHEMBL8547611 | 0.82 | GRIN2B (0.61) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL8549819 | 0.81 | GRIN2B (0.58) | GRIN2BGRIN1ACHE | |
| SCHEMBL27460009 | 0.80 | GRIN2B (0.64) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL7402784 | 0.80 | MAOB (0.65) | GRIN2BGRIN1ACHE | |
| SCHEMBL8542333 | 0.80 | GRIN2B (0.73) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL27389763 | 0.80 | GRIN2B (0.58) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |