Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 4/20 | 0.51 |
| ▸ | PPARA | Q07869 | 4/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549456 | 1.00 | KDR (0.51) | KDRPPARGPPARACYP2C9KCNH2 | |
| SCHEMBL8546582 | 0.91 | KDR (0.52) | KDRPPARGPPARACYP2C9KCNH2 | |
| SCHEMBL8546576 | 0.91 | KDR (0.52) | KDRPPARGPPARACYP2C9KCNH2 | |
| SCHEMBL8544815 | 0.87 | PPARG (0.52) | KDRPPARGPPARACYP2C9KCNH2 | |
| SCHEMBL8544816 | 0.87 | PPARG (0.52) | KDRPPARGPPARACYP2C9KCNH2 | |
| SCHEMBL8545190 | 0.86 | PTPN1 (0.54) | KDRPPARGPPARACYP2C9KCNH2 | |
| SCHEMBL8545185 | 0.86 | PTPN1 (0.54) | KDRPPARGPPARACYP2C9KCNH2 | |
| SCHEMBL8545188 | 0.86 | PTPN1 (0.54) | KDRPPARGPPARACYP2C9KCNH2 | |
| SCHEMBL8551814 | 0.85 | KDR (0.54) | KDRPPARGPPARACYP2C9KCNH2 | |
| SCHEMBL8551816 | 0.85 | KDR (0.54) | KDRPPARGPPARACYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759919-B1 | AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS | AMERICAN HOME PROD (US) | 1998-11-11 | — | — | EP | disclosed |
| US-5532256-A | ORALLY ADMINISTERED ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-02 | — | — | US | disclosed |
| US-5468762-A | Antidiabetic agents for administering by mouth | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-21 | — | — | US | disclosed |