Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 5/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768625 | 0.83 | LRRK2 (0.65) | LRRK2PIM1PRMT5WDR77PIM2 | |
| SCHEMBL16535289 | 0.77 | LRRK2 (0.61) | LRRK2PIM1PRMT5WDR77PIM2 | |
| SCHEMBL1251558 | 0.76 | LRRK2 (0.55) | LRRK2PIM1PRMT5WDR77PIM2 | |
| SCHEMBL31220958 | 0.73 | NPSR1 (0.47) | NOTUMATMNPSR1ROCK1HPGD | |
| SCHEMBL8552255 | 0.72 | ADORA2A (0.44) | LRRK2PIM1NOTUMATMMAPK1 | |
| SCHEMBL14633312 | 0.71 | LRRK2 (0.47) | LRRK2PIM1PRMT5WDR77PIM2 | |
| SCHEMBL5139537 | 0.70 | LRRK2 (0.49) | LRRK2PIM1PRMT5WDR77PIM2 | |
| SCHEMBL30316298 | 0.69 | LRRK2 (1.00) | LRRK2PIM1PIM2NTRK1MAPK1 | |
| SCHEMBL1328336 | 0.69 | LRRK2 (1.00) | LRRK2PIM1PIM2NTRK1MAPK1 | |
| SCHEMBL9598073 | 0.69 | BTK (0.50) | LRRK2PIM1PRMT5WDR77BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |