Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 19/20 | 0.77 |
| ▸ | PPARA | Q07869 | 17/20 | 0.77 |
| ▸ | PPARD | Q03181 | 6/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122908 | 0.92 | PPARG (0.78) | PPARGPPARAPPARD | |
| SCHEMBL12618028 | 0.89 | PPARG (0.75) | PPARGPPARAPPARD | |
| SCHEMBL6959523 | 0.89 | FFAR1 (0.70) | PPARGPPARA | |
| SCHEMBL1123237 | 0.88 | PPARG (0.73) | PPARGPPARAPPARD | |
| SCHEMBL13721507 | 0.87 | PPARG (0.65) | PPARGPPARA | |
| SCHEMBL4389208 | 0.87 | PPARG (0.79) | PPARGPPARAPPARD | |
| SCHEMBL5110945 | 0.87 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL3283978 | 0.86 | PPARG (0.77) | PPARGPPARAPPARD | |
| SCHEMBL6381921 | 0.86 | PPARA (0.70) | PPARGPPARAPPARD | |
| SCHEMBL5098728 | 0.85 | PPARG (0.76) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279485-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-10-09 | — | — | US | disclosed |
| EP-0759919-B1 | AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS | AMERICAN HOME PROD (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0759919-A1 | NEW AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5532256-A | ORALLY ADMINISTERED ANTIDIABETIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-02 | — | — | US | disclosed |
| WO-1995031454-A1 | NEW AZOLIDINEDIONES AS ANTIHYPERGLYCEMIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-23 | — | — | WO | disclosed |
| US-5468762-A | Antidiabetic agents for administering by mouth | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-21 | — | — | US | disclosed |