Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.47 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550374 | 0.92 | EDNRB (0.43) | EDNRBEDNRACA9KDM4EHSD17B10 | |
| SCHEMBL8551061 | 0.90 | EDNRB (0.57) | EDNRBEDNRACA2CA9KDM4E | |
| SCHEMBL8548080 | 0.90 | EDNRB (0.49) | EDNRBEDNRACA2CA9KDM4E | |
| SCHEMBL8546571 | 0.89 | EDNRB (0.47) | EDNRBEDNRACA9KDM4EHSD17B10 | |
| SCHEMBL8550229 | 0.86 | EDNRB (0.48) | EDNRBEDNRACA2CA9KDM4E | |
| SCHEMBL8551085 | 0.85 | EDNRB (0.45) | EDNRBEDNRACA2CA9KDM4E | |
| SCHEMBL8548088 | 0.85 | EDNRB (0.47) | EDNRBEDNRAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8550960 | 0.84 | EDNRB (0.66) | EDNRBEDNRAKDM4EMAPTMEN1 | |
| SCHEMBL8551203 | 0.83 | EDNRB (0.52) | EDNRBEDNRAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8551102 | 0.83 | EDNRB (0.45) | EDNRBEDNRAKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |