SCHEMBL8551167

SCHEMBL8551167

O=c1[nH]c(=O)n(Cc2ccc(OCCCCOc3ccc(Cn4oc(=O)[nH]c4=O)cc3)cc2)o1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.53
PLAT P00750 6/20 0.44
PLA2G2A P14555 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
ALDH1A1 P00352 2/20 0.41
MAPT P10636 2/20 0.41
THRB P10828 1/20 0.41
TP53 P04637 2/20 0.40
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
HRH3 Q9Y5N1 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
TSHR P16473 1/20 0.37
ACHE P22303 1/20 0.37
RAD52 P43351 1/20 0.37
HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8550554 0.98 FFAR1 (0.53) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1
SCHEMBL8546450 0.98 FFAR1 (0.53) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1
SCHEMBL8548383 0.98 FFAR1 (0.53) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1
SCHEMBL8548551 0.98 FFAR1 (0.53) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1
SCHEMBL8546840 0.98 FFAR1 (0.53) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1
SCHEMBL8547419 0.98 FFAR1 (0.53) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1
SCHEMBL8547591 0.98 FFAR1 (0.53) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1
SCHEMBL8545736 0.98 FFAR1 (0.53) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1
SCHEMBL8547496 0.97 FFAR1 (0.53) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1
SCHEMBL8549621 0.95 FFAR1 (0.54) FFAR1PLATPLA2G2AL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed