Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548318 | 0.88 | AR (0.46) | ARCHEK1LMNATSHRATM | |
| SCHEMBL8547990 | 0.83 | NPSR1 (0.50) | CHEK1LMNATSHRATMNPSR1 | |
| SCHEMBL8552195 | 0.83 | AR (0.42) | ARCHEK1LMNATSHRATM | |
| SCHEMBL8549626 | 0.83 | AR (0.42) | ARCHEK1LMNATSHRATM | |
| SCHEMBL8546629 | 0.83 | PARP1 (0.40) | LMNATSHRMAPK1S1PR2TP53 | |
| SCHEMBL8548460 | 0.81 | NPSR1 (0.62) | ATMNPSR1MAPK1TP53ROCK1 | |
| SCHEMBL8547999 | 0.80 | NOTUM (0.43) | ARATMNPSR1NOTUMROCK2 | |
| SCHEMBL30108722 | 0.76 | PDE4A (0.43) | ARLMNATSHRMAPK1S1PR2 | |
| SCHEMBL28934651 | 0.76 | PDE4A (0.43) | ARLMNATSHRMAPK1S1PR2 | |
| SCHEMBL15031985 | 0.75 | PRMT5 (0.53) | ARLMNATSHRATMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |