Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065350 | 0.92 | KDR (0.56) | KDRPDGFRAPDGFRBFGFR2AXL | |
| SCHEMBL8552489 | 0.90 | PDGFRA (0.65) | KDRPDGFRAPDGFRBFGFR2AXL | |
| SCHEMBL8554139 | 0.89 | KDR (0.63) | KDRPDGFRAPDGFRBFGFR2AXL | |
| SCHEMBL8554460 | 0.88 | KDR (0.62) | KDRPDGFRAPDGFRBAXLAURKA | |
| SCHEMBL8552405 | 0.88 | KDR (0.54) | KDRPDGFRAPDGFRBFGFR2AXL | |
| SCHEMBL8551461 | 0.88 | PDGFRA (0.59) | KDRPDGFRAPDGFRBFGFR2AXL | |
| SCHEMBL8552659 | 0.87 | PDGFRA (0.67) | KDRPDGFRAPDGFRBFGFR2AXL | |
| SCHEMBL8556378 | 0.86 | PDGFRA (0.61) | KDRPDGFRAPDGFRBFGFR2AURKA | |
| SCHEMBL8555319 | 0.86 | PDGFRA (0.63) | KDRPDGFRAPDGFRBFGFR2AXL | |
| SCHEMBL8553956 | 0.86 | FGFR2 (0.59) | KDRPDGFRAPDGFRBFGFR2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | claimed |