Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.30 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550966 | 0.92 | EDNRB (0.43) | EDNRBEDNRAGRM2SERPINE1 | |
| SCHEMBL8546593 | 0.92 | EDNRB (0.42) | EDNRBEDNRAGRM2 | |
| SCHEMBL8549580 | 0.90 | EDNRB (0.54) | EDNRBEDNRA | |
| SCHEMBL8551991 | 0.89 | EDNRB (0.52) | EDNRBEDNRASERPINE1 | |
| SCHEMBL8549027 | 0.86 | EDNRB (0.49) | EDNRBEDNRA | |
| SCHEMBL8545781 | 0.85 | EDNRB (0.44) | EDNRBEDNRA | |
| SCHEMBL8550751 | 0.85 | EDNRB (0.46) | EDNRBEDNRASERPINE1 | |
| SCHEMBL8553153 | 0.84 | EDNRB (0.43) | EDNRBEDNRA | |
| SCHEMBL8547912 | 0.83 | EDNRB (0.43) | EDNRBEDNRAGRM2 | |
| SCHEMBL8552533 | 0.82 | EDNRB (0.52) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |